Haiming Chen MD, PhD
Director of Research Laboratory
Dr. Chen became a hematologist in China and passed the United States Medical Licensing Examination (USMLE) in 2002. He currently serves as a reviewer for the Philip Morris External Research Program and is a member of the American Society of Hematology.
Dr Chen received his doctoral degree from Shanghai Jiao Tong University, School of Medicine, Biochemistry Institute, Chinese Academy of Science, and University of Southern California. He completed his postdoctoral training at the University of British Columbia and served as an Assistant Professor at the University of Southern California from 1994 to 2001. Dr. Chen received a NIH training grant (1994-1996) for genetic development biology.
In his research, he has discovered that myeloma tumors produce a protein, pleiotrophin, that assists tumor growth by a completely novel mechanism in which a type of white cell called a monocyte turns into a new blood vessel. This discovery has opened exciting new avenues in the development of treatment for myeloma patients and the paper has been published in the prestigious Blood (Chen H. et al. 1; 110: 287-95, 2007).
Dr. Chen has also developed innovative siRNA technology that has led to new advances in controlling the growth of myeloma tumors in the bone as well as stemming the loss of bone density. The paper, “Interference with nuclear factor kappa B and c-Jun NH2-terminal kinase signaling by TRAF6C small interfering RNA inhibits myeloma cell proliferation and enhances apoptosis” has been published in Oncogene (Chen H. et al. 25; 6520-7, 2006) He continues to design new uses for this technology to target anti-myeloma therapies to specific genes. Furthermore, Dr. Chen led the discovery of a novel platelet binding protein that allowed advancements in research for new therapies for multiple myeloma and lymphoma.